MASON, Ohio -- Novak Djokovic dumped another pressure-packed shot into the net and stood in place for a moment, stunned by another upset in Cincinnati. Its the only place where he cant win. Top-ranked American John Isner ended Djokovics attempt to make ATP history Friday, beating the No. 1 player 7-6 (5), 3-6, 7-5 in the quarterfinals at the Western & Southern Open. Djokovic has never won in Cincinnati, the only Masters event that has eluded him during his career. He has lost in the finals four times, including last year to Roger Federer. All he needs to do is hoist the winners trophy one time in Cincinnati to become the first player to win all nine Masters events. Wait until next year. Again. "Its disappointing that I played this way," Djokovic said. "For me, its very disappointing." Isner reached the semifinals in Cincinnati for the first time, knocking off a No. 1 for only the second time in his career. His other No. 1 upset? He beat Djokovic at Indians Wells in the semifinals last year. "A fantastic win for me," Isner said. "Certainly one of my greatest memories as a tennis player." Hell play seventh-seeded Juan Martin del Potro, who advanced Friday by beating qualifier Dmitry Tursunov 6-4, 3-6, 6-1. Del Potro is in the semifinals for the second straight year. Soon after Djokovic got knocked out, No. 2 Andy Murray was gone, too. He failed to convert a break point while losing 6-3, 6-4 to Tomas Berdych, who also beat him in the quarterfinals at Madrid. They were relegated to the adjoining grandstand court. Both players struggled with the loud music, announcements and cheering from centre court. "I think this was my best moment of the game to handle this because I was struggling with the noise around the court and the distraction," Berdych said. "You know, I handled it pretty well today." Murray? Not so much. At least it got the Wimbledon champion prepared for Flushing Meadows. "I think in some ways its good preparation for the U.S. Open because normally the U.S. Open is fairly loud," Murray said. "You know, a lot of movement and music, and they have the big screen and stuff. So, yeah, you get used to that playing here." In the womens draw, top-seeded Serena Williams needed only 64 minutes to beat Simona Halep 6-0, 6-4. Shell play Li Na, who advanced to the semifinals automatically when No. 4 Agnieszka Radwanska withdrew to attend her grandfathers funeral. Like Djokovic, Williams has never won in Cincinnati, which has become one of her goals. She struggles with the conditions on court and wasnt happy with her overall level of play on Friday. "I have quite a few things on my tennis bucket list," Williams said. "This obviously is one of them. But I like to believe if it doesnt happen this year, I always have another chance." Also, 14th-seeded Jelena Jankovic beat 12th-seeded Roberta Vinci 6-0, 6-4 to reach the semifinals for the third time. She won the tournament in 2009 and lost the title match to Maria Sharapova in 2011. "I love playing here in Cincinnati because I have great results in the past," said Jankovic, who fought off eight of nine break points in the second set. "So that always helps. I mean, I was a finalist and a champion before, so you always love coming back to places where you can win." Not Djokovic. He played poorly last year in his loss to Federer in the final. He was off again Friday, which was especially frustrating since he came into the tournament motivated to make ATP history. "I just played a very bad match overall," he said. "Terrible match. From beginning to end, except the start of the second set, I was just a different player totally." Djokovic wasted a chance to break Isner early in the third set. He was up 40-15 in the final game, ready to send it to a tiebreaker, when he came apart. Isner kept the game going with a running forehand that hugged the line, drawing a loud cheer from the crowd. "Probably the best shot I hit all match," Isner said. Djokovic gave Isner his first attempt at a match point by dumping a backhand into the net, but saved it with a 119 mph ace. With the crowd cheering Isner on, Djokovic double-faulted and dumped another backhand into the net, giving Isner his only service break of the match. What happened? "I dont know," Djokovic said. Del Potro has been playing with a sore wrist and knee, two concerns with the U.S. Open at hand. He managed to reach the semifinals without issue. "Its bothering me a little bit, but not too much," he said. "(Im) trying to play a slice and play different shots in this tournament before the U.S. Open to see how different I can play against the top guys or doing different things." "Im OK," he added. "My knee is OK, too, and thats important looking forward to New York." Under Armour Canada Outlet .500 on the season. The Jets are now 0-5-1 in the second game of back-to-backs. 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Takahashi, who had a 10-point lead after the short program, received 268.31 points after the free skate to finish 15 points ahead of second-place Nobunari Oda. NEW YORK -- Even before the Chicago Cubs got to celebrate their drought-ending World Series title with a parade, baseballs business season began Thursday when more than 100 players became free agents and teams started making decisions on 2017 options.Among the potential free agents are outfielders Yoenis Cespedes, Jose Bautista, Mark Trumbo, Josh Reddick and Ian Desmond; first baseman Edwin Encarnacion; catcher Matt Wieters; and closers Aroldis Chapman, Kenley Jansen and Mark Melancon. They can start talking money with teams on Tuesday.Clubs must decide by Monday whether to make $17.2 million qualifying offers to their players who became free agents, which would attach draft-pick compensation if they sign elsewhere. Only players who spent the entire season with one team are eligible for the offers.Texas said it will make a qualifying offer to Desmond, and the two-time All-Star will have until Nov. 14 to accept.In the first trade since the World Series, the Los Angeles Angels acquired outfielder Cameron Maybin from the Detroit Tigers for right-hander Victor Alcantara.Maybin batted a career-best .315 with four homers, 43 RBI and 15 stolen bases in 94 games this year for the Tigers, posting one of his best big league seasons despite injury problems. The Angels said they will exercise his $9 million option.The 23-year-old Alcantara has spent five years in the Angels minor league system. He went 3-7 with a 4..dddddddddddd.30 ERA in 29 appearances for Double-A Arkansas last season.Among potential free agents, Philadelphia declined a $23 million club option on first baseman Ryan Howard, who gets a $10 million buyout, and a $9.5 million mutual option on right-hander Charlie Morton, who gets a $1 million buyout.Boston exercised a $17.2 million option on designated hitter David Ortiz as a formality, even though the 40-year-old slugger has said he will retire.The team also exercised a $13 million option on right-hander Clay Buchholz and declined a $3.75 million option on catcher Ryan Hanigan, who gets an $800,000 buyout.Others whose options were exercised include Mets outfielder Jay Bruce ($13 million) and infielder Jose Reyes (minimum salary), Washington left-hander Gio Gonzalez ($12 million), Detroit closer Francisco Rodriguez ($6 million), Seattle outfielder Seth Smith ($7 million), Texas catcher Jonathan Lucroy ($5.25 million) and San Francisco left-hander Matt Moore ($7 million).Among those whose options were declined were Chicago White Sox pitcher Matt Albers, Seattle catcher Chris Iannetta, Miami reliever Fernando Rodney, Mets left-hander Jon Niese and Washington right-hander Yusmeiro Petit.In another move, the Houston Astros claimed outfielder Nori Aoki off waivers from Seattle. 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